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  • Light Engines for the Life Sciences

    Thursday, September 04, 2008
    Technical Article
    Arlie R. Conner Claudia B. Jaffe Steven M. Jaffe
    Life science instruments present unique challenges to suppliers of light-generation equipment: Inexpensive, high-intensity, uniform, monochromatic light across a broad UV-VIS-IR spectrum is required... read more

  • PCR Amplification Performance Comparison

    Thursday, January 24, 2008
    Technical Article
    Pauline Littlewood Vikki Mitchell
    Microbiological testing is a large and expanding worldwide market encompassing both research and industrial sectors. read more

  • When Analyzing Cancer at the Molecular Level, Microliters Matter

    Friday, November 30, 2007
    Technical Article
    This year, more than 1.4 million Americans will be diagnosed with cancer. An extremely complex disease family, cancer affects all types of people, from all nationalities and genetic make-ups. read more

  • Ion Exchange for Proteomics

    Thursday, February 01, 2007
    Application Note
    Xueying Huang Virginia McKay
    Ion exchange is particularly well suited to the separation of biological molecules; however, limitations of HPLC packing materials have restricted its use. Silica-based ion-exchange materials are pH ... read more

  • Ultrasensitive Measurement of Protein and Nucleic Acid Biomarkers for Earlier Disease Detection and ...

    Friday, January 19, 2007
    Technical Article
    Gregory Shipp
    It is a universal fact substantiated by decades of biopharmaceutical research: the earlier a disease is detected, the more likely treatments will be effective in alleviating or stabilizing the disease... read more

  • Whole Genome Amplification: Extending Beyond the Limitations of Traditional PCR

    Monday, April 04, 2005
    Technical Article
    Alicia Pruett Tony Favello Ernie Mueller
    The history of molecular biology is marked by technological advances that have opened up the investigation of both fundamental and applied biological problems. read more

  • A Practical Guide to Publishing RT-qPCR Data That Conform to the MIQE Guidelines

    Tuesday, March 23, 2010
    Technical Article
    Sean Taylor
    Real-time quantitative PCR (qPCR) has become a definitive technique for quantitating differences in gene expression levels between samples. read more

  • Putting the “More” in Morphology: Part 2

    Wednesday, April 10, 2013
    Technical Article
    Barbara Foster
    Part 1 of this article discussed the impact of multiplexing morphological methods, multiparametric techniques, and supervised machine-learning to answer the question "what" is there, as well as "where... read more

  • Multiparameter Pluripotency Analysis Using Magnetic Bead Assays

    Wednesday, August 28, 2013
    Application Note
    Nikolai Stankiewicz Thomas Siegl Frederick Wiese
    For the application of induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) to regenerative medicine and drug discovery research, it is crucial to characterize the identity ... read more

  • Integrating Microscopy Into the Analytical Scheme: A Pittcon® 2014 Microscopy Review

    Monday, February 24, 2014
    Technical Article
    Barbara Foster
    Microscopy is often overlooked at Pittcon®, yet of the 12,000+ scientists who attend, approximately 30% use microscopy in some form (according to ongoing research from The Microscopy & Imaging Place, ... read more

  • Single-Cell RNA Detection to Identify Cell Subpopulations in Heterogeneous Mixtures

    Tuesday, March 25, 2014
    Application Note
    Don Weldon Victor Koong Alex Ko Yuko Williams Laura White
    Traditional RNA detection methods, which analyze RNA levels in lysed, permeabilized, or fixed cell samples, make it challenging to understand the role of one gene in the context of a tissue, organ, or... read more

  • New Solutions for Surface Texture Analysis

    Monday, November 01, 2010
    Technical Article
    Barbara Foster
    Most microscopists are familiar with confocal microscopy from neuroscience or cell biology. However, very quietly and abruptly, confocal has jumped the fence into industry, becoming a major tool-of-... read more

  • Confidence Up Close

    Friday, January 01, 2010
    Application Note
    Aubrey Lambert
    The combined pressures of continuing miniaturization, higher packing densities, and rigorous quality assurance means that the physical size of particles capable of adversely affecting industrial ... read more

  • Enabling Cancer Research and Treatment With Droplet-Based Digital PCR Technology

    Wednesday, September 03, 2014
    Application Note
    George Karlin-Neumann
    Cancer research is as necessary as ever, especially if we are to fulfill the promise of personalized (or “precision”) medicine based on specific cancer therapies directed to known molecular targets. read more

  • DNA in Forensics

    Wednesday, August 28, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The proliferation of forensic DNA testing and databases by state and local jurisdictions was recently reported by Joseph Goldstein in The New York Times. For years, the FBI’s combined indexing system ... read more

  • 2014 Emerging Clinical & Laboratory Diagnostics: The Portable Lab

    Monday, October 06, 2014
    Technical Article
    Robert L. Stevenson, Ph.D.
    For decades, the clinical laboratory has been recognized as the leading model for applied analytical chemistry labs. Clinical chemists are the first to deal with real-world concerns such as large-... read more

  • Top Considerations When Automating Your Real-Time PCR Workflow

    Thursday, October 16, 2014
    Application Note
    Jennifer Reed Kim Petro
    With the increasing importance of large-scale data generation, many pharmaceutical labs are using robots to speed data collection. One such strategy is to automate the real-time PCR workflow. read more

  • 45 Years of American Laboratory

    Friday, October 04, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    October 1988: I remember it well. My lab overlooked the parking lot at Varian Associates. We were expecting a visit from Bill Wham and Ken Halaby, the founders of American Laboratory magazine. read more

  • Improved Long-Term Culture Using A Microfluidic Platform

    Monday, October 07, 2013
    Application Note
    Alex Mok Paul Hung Cindy Chen Sónia Gil Kathleen Ongena
    Precise and biologically relevant in vitro studies require the ability to analyze cell responses to perturbations over time. In order to achieve successful long-term cell culture and imaging, however,... read more

  • Use of qPCR to Detect Biomarkers for Assessing Stem Cells

    Saturday, October 01, 2011
    Technical Article
    Jaime Sabel
    In the human body, undifferentiated stem cells are the raw material used to repopulate tissues and organs in response to accidental cell death or normal cell turnover. read more
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